PREVENTION OF BISPHENOL A INDUCED HISTO-PATHOLOGICAL INSULTS TO URINARY CORPUSCLE OF ALBINO RAT KIDNEYS BY MORINGA OLEIFERA
Abstract
Background: The use of medicinal herbs has been in practice in our society since ages. Similarly with the evolution of plastics, the use of plastic ware has increased in the past few decades. Along with other injurious substances, it contains Bisphenol A, that is a known deleterious agent for human health. Now a days modern medicine has evolutionized and taking refuge in using herbal substances in preparing allopathic medicines too. One such medicinal plant being studied far and wide for its excellent antioxidant properties is Moringa oleifera.
Objectives: To establish the protective effects of Moringa leaves in renal damage induced to renal corpuscle of albino rat kidneys by Bisphenol A.
Method: A total of 30 adult albino rats of either gender were taken and made three groups A, B and C each of which contained 10 rats. The group A, was control. The group B, BPA-exposed, was ingested with 50mg/kg of BPA. The third group, C, was simultaneously administered 400mg/kg MoLE along with 50 mg/kg BPA. Rat kidney specimens were histologically evaluated by hematoxylin and eosin staining. The experimentation took total eight weeks investigated the probable efficacies of leaves of Moringa Oleifera in comparison to histo-pathological alterations in the renal corpuscles of albino rats induced by BPA.
Results: The results depicted that BPA exposure resulted in renal corpuscle damage in the rat kidneys as evident via increased urinary space diameters along with glomerular congestion noticed in the group B. However, rats getting MoLE indicated notable absence of these histopathological alterations. This shielding provided by MoLE against BPA may be credited to its nutritiously active contents like polyphenols and flavonoids, which fight oxidative injuries as well as inflammation.
Conclusion: This study guides us into the large number of medicinal benefits of Moringa plant including its role in prevention of oxidative injuries being caused by toxins like BPA to renal corpuscles in rat kidneys.
