EFFICACY OF DIFFERENT DOSAGE REGIMENS OF CARBIMAZOLE IN TREATMENT OF PRIMARY HYPERTHYROIDISM

Abstract

Objectives: To determine the efficacy of different carbimazole regimens in treatment of primary hyperthyroidism

Methods: This study was conducted at Medical Ward of Mayo Hospital Lahore from September 2023 to March 2024 on 100 patients with primary hyperthyroidism. Patients were assigned to two groups; Group A received carbimazole once a day, whereas Group B were prescribed with divided doses of carbimazole, which were modified based on results of TFTs.

Results: Among 100 patients enrolled (50 in Group A and 50 in Group B), there were no significant differences in baseline levels of TSH and T4, nor in their overall rates of reduction. Additionally, both groups showed comparable rates Of Achieving Euthyroidism During Follow-Up Assessments Conducted At Three-Month Intervals.

Conclusion: When administered in single daily dosing regimen, carbimazole is similarly successful in treatment of hyperthyroidism as daily divided dose regimen. Additionally, it raises the patients' compliance when taken as a single dosage every day.